Any drug that is designed to be given orally, i.m. s.c. or i.v. and acts on the brain MUST cross the blood-brain barrier.
E.g. Opiates, anxiolytics, SSRI's, anti-psychotics
Drug needs to be lipid (fat) soluble to cross the BBB.
The intracranial pressure is decreased by intravenous mannitol
The intracranial pressure is decreased by the administration of sodium nitroprusside
The intracranial pressure is decreased by hyperventilation
The oxygen dissociation curve is shifted to the right with decreased concentration of2, 3-DPG in the erythrocytes.
Compliance
The intracranial pressure is decreased by placing the patient in a head-up position
The oxygen dissociation curve is shifted to the right with pyrexia
ABO and rhesus (Rh) system, d. rhesus antibodies occur naturally
Concerning the flow rate of air into or out of the lungs
ABO and rhesus (Rh) system, a person of group O is a universal donor
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