No. Spaces are generally added for clarity. Some compilers get upset if you write things like " INTEGERI,J" rather than INTEGER I,J". Simple neatness will keep you out of these problems. Remember that a space is required in column 6 if you aren't continuing from the previous line. The following are all equivalent:

x=x*y**2*sin(x)

x=x * y**2 * sin(x)

x = x * y ** 2 * sin ( x )